The football-mad country has a population of 90 million and the Gunners believe they can add to an already sizeable fan base there by playing a friendly match.
Arsenal will spend three days promoting the club in the communist country's capital Hanoi from July 15-17 and will field a full-strength team against the national side at the My Dinh National Stadium on the final day,
Italian giants AS Roma will also play in Vietnam, seven weeks earlier than Arsenal on June 2, according to Vietnam's state media.
Arsenal has for several years given support to Vietnamese football through a local project aimed at developing young players, the Hoang Anh Gia Lai-Arsenal JMG Academy.
Arsenal have already announced a match in Jakarta, Indonesia and they also plan to play one other match in Asia.
Traditionally manager Arsene Wenger has preferred to prepare for the new season in Austria but commercial pressures have led to this move to Asia in recent years.
Liverpool, Manchester United, Chelsea and Manchester City will also all fly to Asia for pre-season matches.
Such are the demands of United's trip, where they will take-in games in Bangkok, Sydney, Yokohama, Osaka and Hong Kong, that they are expected to travel close to 24,000 miles.
To put that into the context, the circumference of the world is just slightly bigger than that at 24,900 miles.