Del Bosque has admitted concerns over David Villa's lack of action at Barcelona, but could turn to Michu - with 12 goals in the Premier League this season - and Chelsea forward Fernando Torres, who has hit 11 goals in all competitions, including two in the 3-1 win at Sunderland last Saturday.
Spain are next in action in a friendly match with Uruguay in Doha on February 6 before they continue their World Cup qualifying campaign against Finland and France in March.
“I do not know what has happened with Villa, I have no idea,” said Del Bosque.
“Barcelona play many games. I am certain he will have a chance to play and that most important is how his recovery from his injury is handled and that is down to the coach to handle as best as possible.
“And Torres? He is playing, he is scoring goals and he seems to have been slightly revived at Chelsea with the arrival of Rafa Benitez. I think it is a good time for all the forwards, Aduriz, Negredo, Soldado are still scoring goals, Iago Aspas and Michu too, there are a lot of players.”
Del Bosque distanced himself from comments made by Arsenal manager Arsene Wenger suggesting Spain will not successfully defend the World Cup at the 2014 finals tournament in Brazil.
"Those are words, then there is the reality on the field. Opinions are there to be respected," said Del Bosque.
“It is true that we will have to play the World Cup in Brazil, if we qualify and that the South American countries will naturally be split as favourites, because Argentina and Brazil are both very strong, whilst now there are countries like Colombia, Ecuador, Venezuela that were once marginalised but can be included, whilst Chile, Uruguay and Paraguay are capable of anything.”