And just seconds later Meyler struck to put the Tigers on the road to a famous triumph.
It means Liverpool remain seven points adrift of the Gunners after slumping to a third league loss of the campaign.
PRE-MATCH: Chance for Bruce jnr, Sturridge blow - Steve Bruce hands his son, Alex only his second Premier League start in place of the injured Paul McShane. But it was the news that Daniel Sturridge will miss up to eight weeks with an ankle injury that dominated the pre-match chatter. A big blow for the Reds who face seven games in 29 days.
20' - GOAL: Hull City 1-0 Liverpool - Jake Livermore's 25-yard strike takes a wicked deflection off Skrtel and loops into the far corner.
27 - GOAL: Hull 1-1 Liverpool - Gerrard steps up and curls a delicious free kick into the far corner from 25 yards out. A great way to mark 15 years in Liverpool's first-team.
71' - SAVE: Allan McGregor pulls off a sensational point-blank save to deny Moses.
72' - GOAL: Hull 2-1 Liverpool - Woeful defending from the visitors sees Toure only half clear the ball to David Meyler who makes no mistake with a crisp shot across Mignolet.
87' - GOAL: Hull 3-1 Liverpool - It's all over. Huddlestone's tame shot deflects off Skrtel and flies into the net.
Hull City secure their first ever win over Liverpool at the 17th time of asking.
Liverpool have kept just one clean sheet in their last 10 Premier League matches.
Steven Gerrard has scored four goals in four Premier League appearances against Hull City.
Liverpool have now won only three of their last 13 PL away matches against promoted teams (D3-L7).
Hull score three goals in a PL home match for the third time. The previous two occasions came in consecutive home matches in November 2009, 3-3 v West Ham and 3-2 v Everton.
Martin Skrtel scores his third PL own goal for Liverpool. They lost both the previous matches he put the ball in his own net (2-1 at Spurs in Nov 2010 and 1-0 at home to Fulham in May 2012).
TALKING POINT: Will the Sturridge blow derail Liverpool? The Reds certainly lacked a cutting edge here. The England striker's partnership with Luis Suarez has been hailed as one of the best in Europe and both hitmen have consistently plundered the goals that have been key to the Reds' impressive start. With a hectic festive period just around the corner, Sturridge's injury comes at a bad time for Brendan Rodgers and how they cope over the next two months will no doubt play a defining role in their season.
MAN OF THE MATCH
Curtis Davies (Hull City): A rock at the back who helped keep Luis Suarez at bay throughout. Dangerous at set pieces at the other end too.
PLAYER RATINGS -
HULL CITY: McGregor 7, Elmohamady 7, Figueroa 6, Davies 8, Bruce 7, Meyler 7, Huddlestone 7, Livermore 7, Brady 7, Koren 6, Sagbo 7. Subs: Rosenior 6, Graham 5, Boyd 5.
LIVERPOOL: Mignolet 6, Johnson 5, Flanagan 5, Skrtel 6, Toure 5, Lucas 5, Henderson 5, Gerrard 6, Sterling 5, Moses 5, Suarez 6. Subs: Coutinho 6, Alberto 5.
THE MATCH IN A TWEET