Click the links for full previews of every game.
MANCHESTER UNITED v STOKE CITY - 15:00
United welcome back Ashley Young from injury while Stoke hope to use ex-Reds striker Michael Owen.
SWANSEA v WIGAN - 15:00
The Swans have been forced to refute reports of a dressing room mutiny, while Wigan boss Roberto Martinez returns to the club he left for the Latics.
WEST BROM v MANCHESTER CITY - 15:00
The Baggies are performing well above expectations this season but it is a tough ask against the defending champions, who are without David Silva but have well-rested France exile Samir Nasri as a replacement.
WEST HAM v SOUTHAMPTON - 15:00
The Hammers are steadily climbing the table and will have Andy Carroll leading the line against a Saints side depleted by a long-term injury to record signing Gaston Ramirez.
LIVERPOOL v READING - 15:00
Things went from bad to worse for the Reds when forward Fabio Borini was ruled out for three months, while Reading will be hoping to climb out of the bottom three.
FULHAM v ASTON VILLA - 15:00
Dimitar Berbatov returns for the Whites, as does Mahamadou Diarra, while Villa boss Paul Lambert tries to dig his young side out of a hole.
NORWICH CITY v ARSENAL - 17:30
Norwich's poor start to the season does not get any easier for boss Chris Hughton, while Arsenal are set to welcome back Jack Wilshere to the squad, although he is not expected to play.
SUNDERLAND v NEWCASTLE - 13:30
The big North East derby is bound to be a fiery affair, with both sides desperate for a win after 3-0 defeats to the Manchester sides last time out. Sunderland boss Martin O'Neill must decide whether to rest Danny Rose after he was the victim of racial taunts on U21 duty in Serbia.
QPR v EVERTON - 16:00
The Hoops have had a rotten start to the season, without a win in seven matches, while Everton have been the surprise package. The Toffees are without talismanic midfielder Marouane Fellaini though.