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Liverpool will make widespread changes after putting out an inexperienced side to face Young Boys in the Europa League. Wayne Rooney has not made it back in time to feature for United while Ashley Young is another absentee.
Cheick Tiote could make his return from a calf injury to feature for Newcastle, who are also strengthened by the return of Papiss Cisse after he missed the Europa League game against Maritimo due to injury.
Brad Friedel will return in goal after Hugo Lloris was preferred in the Europea League. Meanwhile, QPR have been beset by injuries with Andy Johnson out for most of the season and Fabio and Anton Ferdinand both ruled out.
Samir Nasri misses the game against his former side but Sergio Aguero is fit to return in attack for City. Arsenal are again without goalkeeper Wojciech Szczesny due to injury.