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Captain Vincent Kompany (thigh) remains on the sidelines while David Silva and striker Stevan Jovetic (calf) are also still sidelined; Andre Villas-Boas has revealed that striker Emmanuel Adebayor could make his first appearance of the season.
Striker Andreas Cornelius returns from an ankle injury for Cardiff; David Moyes must decide whether Nemanja Vidic will be fit enough to skipper his team. Vidic needed hospital treatment after suffering concussion against Arsenal immediately prior to the international break.
West Brom striker Nicolas Anelka could make his return to first-team action; Christian Benteke is a doubt for Villa.