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(15:00 unless stated)
Wigan are without left-back Maynor Figueroa for the remainder of the season while West Brom have striker Marc-Antoine Fortune suspended.
Under-pressure Newcastle have problems in defence with Davide Santon, Massadio Haidara and Tim Krul all absent.
Chico Flores is an injury doubt for Swansea. Manchester City have doubts over Maicon and Jack Rodwell.
Reading midfielder Hope Akpan is available after an ankle problem and may figure.
Goalkeeper John Ruddy is in contention to make his return for Norwich after five months out with a thigh injury. Aston Villa could be without defender Ciaran Clark and midfielder Karim El Ahmadi again.
Newly-crowned PFA Player of the Year and Footballer of the Year Gareth Bale will start for Spurs, but Moussa Dembele is a doubt.
Arsenal are still without Olivier Giroud due to suspension while goalkeeper Lukasz Fabianski remains sidelined with a rib injury.
Liverpool are without the suspended Luis Suarez and the injured Joe Allen as Jamie Carragher plays his final Merseyside derby.
Danny Welbeck misses out for United but Paul Scholes is expected to be on the bench after being sidelined since January with a knee problem. Demba Ba comes back int contention for Chelsea, while Juan Mata will also start.
Sunderland are without key forward Stephane Sessegnon after his red card in the 6-1 defeat to Aston Villa.