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West Brom will be without Nicolas Anelka, with the striker having been given indefinite compassionate leave following the death of his agent Eric Manasse.
Andy Carroll is denied the chance to face his former side as he is still struggling with an ankle injury; Newcastle are undecided as to whether Yohan Cabaye should play following interest from Arsenal.
Southampton manager Mauricio Pochettino has confirmed new signing Pablo Osvaldo is in contention to play some part; Sunderland boss Paolo Di Canio looks set to keep faith with central defender Valentin Roberge.
Winger Jason Puncheon could go straight into Crystal Palace's side for Saturday's trip to Stoke.
Suspended Liverpool striker Luis Suarez remains the only notable absentee for his side; Aston Villa should have defender Ciaran Clark available. Clark was forced off in the first half of the 2-1 loss at Chelsea.
Left-back Ben Davies may return for Swansea after missing out against Petrolul Ploiesti in the Europa League through injury.
All eyes are on Wayne Rooney as David Moyes decides whether to start the striker against the club that are hoping to sign him before the window closes.