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Skipper John Terry is missing for Chelsea, along with Eden Hazard. Everton are deprived of midfielder Leon Osman.
QPR striker Loic Remy is available after being bailed following his arrest on suspicion of rape, a claim he denies. Liverpool are without Luis Suarez and Steven Gerrard.
Manchester City were assessing defender Kolo Toure and striker Sergio Aguero as caretaker Brian Kidd prepares to take charge again.
Arsenal have a major doubt over Mikel Arteta (calf). Jack Wilshere, set to have an operation on his troublesome ankle next week, is on stand-by should he deemed fit enough to start and play on painkillers. Olivier Giroud returns from a three-match suspension.
Striker Rickie Lambert and talented young left-back Luke Shaw are doubts for Southampton.
Swansea could be unchanged after losing to Manchester United while Steve Sidwell is still suspended for Fulham.
Defender Benoit Assou-Ekotto has recovered from a knee injury but long-term absentees Sandro (knee), Younes Kaboul (thigh) and William Gallas (calf) are unavailable. Sunderland boss Paolo Di Canio will need to plug the hole left by loan signing Danny Rose.
West Brom right-back Steven Reid is head coach Steve Clarke's only injury doubt. Sir Alex Ferguson is set to leave Nemanja Vidic and Rio Ferdinand on the bench for his final game as Manchester United manager.
Andy Carroll plays his final game for West Ham before his loan spell from Liverpool ends.
Wigan winger Callum McManaman will miss the game after suffering an ankle injury. Aston Villa will be without suspended striker Christian Benteke.