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Argentina internationals Fabricio Coloccini and Jonas Gutierrez will miss out for Newcastle; defenders Glen Johnson and Aly Cissokho return to Liverpool's squad.
Striker Fernando Torres could return from a knee injury sooner than expected, but Ashley Cole (ribs) and Andre Schurrle (leg) are out; striker Andreas Cornelius remains the only injury absentee for Cardiff.
Midfielder Gareth Barry returns after being ineligible to face Manchester City before the break but Everton are without Darron Gibson due to a long-term injury; Hull's top-scorer Robbie Brady is set for a swift return to the squad having missed only one match since undergoing a hernia operation.
Tom Cleverley misses out for United after withdrawing from the England squad last week; Artur Boruc and Luke Shaw are both in contention for Southampton.
Stoke are waiting on the fitness of Geoff Cameron; goalkeeper Ben Foster (foot) and winger Scott Sinclair (hamstring) are out for West Brom.
Striker Steven Fletcher will return to the Sunderland squad for Gus Poyet's first game as Black Cats manager.
West Ham defender James Collins will miss out after suffering an injury with Wales; Manchester City captain Vincent Kompany has been ruled out with a thigh injury.
Paul Lambert is assessing Christian Benteke's fitness before deciding whether to throw the striker back into action; Tottenham are missing defenders Younes Kaboul and Danny Rose.
Scott Parker could be back in Fulham's line-up. The midfielder has been sidelined with a calf problem, but subject to a fitness assessment, will make a welcome return to Martin Jol's squad.