"Cycles come to an end but good times are unforgettable," Resino said in a statement on his personal website.
"These last few months Granada, their fans and people, have filled me with fond memories that I will always carry with me."
The former Atletico Madrid goalkeeper and coach was brought in to replace Fabriciano Gonzalez in January and steered them away from a swift return to the second division to a 17th-placed finish last month.
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