Edinburgh wing Lee Jones is to make his Scotland debut in the RBS 6 Nations opener with England at Murrayfield on Saturday.
Scotland head coach Andy Robinson has made eight changes from the team which began Scotland's most recent Test, the 16-12 Rugby World Cup loss to England in Auckland last October.
The uncapped Jones is joined in being promoted to the starting line-up by lock Jim Hamilton, flanker Ross Rennie, number eight David Denton, scrum-half Chris Cusiter, fly-half Dan Parks, centre Nick De Luca and full-back Rory Lamont.
Jones and Edinburgh team-mate Denton are the only members of the starting XV who did not travel to the World Cup in New Zealand.
Hooker Ross Ford is to captain the side, with Allan Jacobsen at loosehead prop and Euan Murray at tighthead. World Cup skipper Alastair Kellock has been replaced in the second row by Hamilton, who will partner Richie Gray.
Alasdair Strokosch is retained at blindside flanker, with Rennie taking the place of John Barclay at openside and Denton, who has one cap, succeeding Richie Vernon at number eight.
Cusiter and Parks replace Mike Blair and Ruaridh Jackson, who is out injured, at half-back, with a centre combination of Sean Lamont and De Luca, who replaces the injured Joe Ansbro.
Max Evans is to line up on the wing, with Jones on the other flank in place of Simon Danielli. Rory Lamont takes the place of Chris Paterson, who retired last month following 109 caps.
Scotland team: R Lamont (Glasgow Warriors); L Jones (Edinburgh), N De Luca (Edinburgh), S Lamont (Scarlets), M Evans (Castres); D Parks (Cardiff Blues), C Cusiter (Glasgow Warriors); A Jacobsen (Edinburgh), R Ford (capt, Edinburgh), E Murray (Newcastle), R Gray (Glasgow Warriors), J Hamilton (Gloucester), A Strokosch (Gloucester), R Rennie (Edinburgh), D Denton (Edinburgh).
Replacements: S Lawson (Gloucester), G Cross (Edinburgh), A Kellock (Glasgow Warriors), J Barclay (Glasgow Warriors), M Blair (Edinburgh), G Laidlaw (Edinburgh), G Morrison (Glasgow Warriors).