Chris Fusaro returns at openside flanker, with Rob Harley on the blindside and Ryan Grant at loosehead prop, while Kellock's understudy at second row is Jonny Gray.
The younger brother of Scotland lock Richie Gray has been named on the bench and is in line to make his professional debut.
Out of the starting XV go prop Gordon Reid, lock Tom Ryder, injured flanker John Barclay (leg) and blindside flanker James Eddie. Tighthead Moray Low and hooker Pat MacArthur complete the front row, with Ryan Wilson at number eight.
There is a solitary change in the back-line from the side which lost 10-8 to Castres in the Heineken Cup last weekend, with Peter Murchie at full-back and Sean Maitland shifted to the wing, Tommy Seymour dropping out of the squad.
Glasgow head coach Gregor Townsend said: "I was very pleased with way we attacked Castres for long spells of the game last week, the players showed ambition, pace and intensity.
"If we're to win this game on Friday we need to have a similar level of performance. We're preparing for a very tough contest against one of the best attacking teams in the PRO12. They can put out a very strong pack with a number of different ways of playing so we need to be absolutely on top of our game.
"It's a massive occasion for Scottish rugby and there's a lot at stake for both teams. I expect a lot of intensity on both sides and with the RBS 6 Nations not too far away, there is no doubt about added motivation around selection for the national team.
"For us, the focus has to be on our position in the PRO12 and over the course of the next two games there are points which can propel us back towards the play-off places."
DTH Van der Merwe is on the opposite wing to Maitland, with Peter Horne and Sean Lamont at centre, Niko Matawalu at scrum-half and fly-half Ruaridh Jackson completing the back line. Five Scotland internationals have been named on the bench.