The Scotland back, who played fly-half during the autumn internationals, will play at either scrum-half or number 10 on Friday at Scotstoun in the RaboDirect PRO12 clash. Edinburgh captain Laidlaw will discover his position on Thursday, when head coach Michael Bradley rules whether or not outside centre Nick De Luca is fit to play following a facial injury.
"I've played the majority of my rugby at 10 of late and I've had a couple of runs at nine," Laidlaw said. "I'm very comfortable. I've trained in both positions through the week. We've picked up a couple of injuries within the squad, which is unfortunate, and Michael's not 100 per cent sure where he wants to go with me because of the injuries."
Edinburgh are seventh in the table ahead of the derby double header - the aggregate score of which determines the destination of the 1872 Cup - and seeking to overhaul the seven-point deficit to the Warriors.
Laidlaw hopes the capital men can win the bragging rights with Glasgow claiming the trophy in each of the last three seasons in matches which are often billed as Scotland trials, given their proximity to the RBS 6 Nations.
Laidlaw added: "Going into these games you definitely want to play well and if you can get the better of your opposite number that's obviously a good thing from a personal note. The most important thing for myself is winning the games.
"They tend to be scrappy affairs sometimes because everyone's getting stuck in so much. As a group of players we're ready for the challenge and we look forward to it."
Edinburgh have won their last two RaboDirect PRO12 matches, but are without a point from four Heineken Cup fixtures in a tough pool and lost 15-3 at home to Racing Metro last Friday. Bradley is eager to claim the trophy for the first time by the end of the second match, at Murrayfield on December 29.
The Irishman said: "After the game at Firhill (in January) the Glasgow players weren't shy in letting us know they'd won it. We want to reverse that and that's what it's about.
"They're derby matches. It's going to be a battle. We're looking forward to it. It's going to be very close. Both sides will be strong on the day and I've no idea how it's going to go, but I hope we win."