The system of hosting a full round of Super League fixtures in the same venue over the course of a weekend began at Cardiff in 2007 and has existed ever since, heading to Edinburgh in 2009 and 2010, before going back to Cardiff in 2011. This year it was held in Manchester, the weekend's first outing in England.
A crowd of 63,716 headed to the home of the Premier League champions in May, and next year's event will be held over the Bank Holiday weekend of May 25 and 26.
"It gives me great pleasure to be able to confirm that the Etihad Stadium will again host the Super League Magic Weekend in 2012," said Super League chief executive Nigel Wood.
"It was clear from the feedback we received from this year's event that the overwhelming majority of fans had a fantastic experience at the stadium and were keen to return."
The RFL have yet to confirm the fixtures - the full season's games are announced next Monday - but it is widely expected that last year's derby game format will be replicated.