The decision comes just two days after the City Reds lost 38-4 at home to London Broncos which saw them slip to the foot of the table after five rounds.
Salford chief executive Ed Farish said: "We have had to look at the whole business and what is right for the club. The results speak for themselves and it was felt a change must be made to allow our progression to continue on the field as well as off it."
