Sam Tomkins helped himself to four tries, while Josh Charnley and Pat Richards both crossed for hat-tricks with the Australian winger adding eight goals for a personal tally of 28 points.
Wigan booked their place in the fifth round of the competition with a 60-10 hammering of Leigh and Wane fielded a very strong team with only Blake Green, Michael McIlorum and Liam Farrell missing out. Wane said: "I am very happy with that performance. This is a very important competition and happy to get through."
He added: "I was impressed with Leigh and I have to commend them, I was pleased with a lot of our execution especially when you consider near the end of the game we had possibly our youngest ever half-back combination in the history of the club with an 18-year-old and a 20-year-old."
Wane handed debuts to youngsters James Greenwood and George Williams and the Wigan boss was happy with how they played and promised to use them again this season.
He added: "I was happy with how both went, they weren't fantastic but they were good for their first game and it is a big step up.
"I don't know what other Super League clubs do but they are under quite a bit of pressure to play a certain way with us so it's not the easiest of debuts for them. I thought they both acquitted themselves very well and I was okay with their debuts."
Leigh coach Paul Rowley was extremely proud of his side, despite conceding 11 tries, and believes his players can be proud of themselves.
He said: "I don't like losing but it's the display that counts sometimes and I'm very proud of the display if I'm being honest. We spoke as a team about coming away with something we could be proud of individually and I think everyone will have one fond memory from this game.
"Like I say I don't like losing but we are always confident whoever we play but it is the performance that matters and they get a tick for that one."