The veteran stand-off scored his 149th try for the club just three minutes after entering the action. The former Welsh international also went on to kick the 1,000th goal of his career while former Salford favourite Stefan Ratchford, who deputised at stand-off during Briers' absence, demonstrated his versatility by switching to centre from where he scored his second try of the match.
Chris Hill opened the scoring for Wolves, with Joel Monaghan, Brett Hodgson and Micky Higham also weighing in with tries. Jodie Broughton prevented a whitewash with a score for Salford near the end before Paul Wood replied with yet another for Warrington.
On a weekend of celebration for the town of Wigan, the rugby league side took another step towards replicating the football team's victorious Wembley appearance by knocking out Hull KR to reach the quarter-finals of the Challenge Cup with a 46-14 win.
After a tricky start they lived up to their favourites tag. Four-try Sam Tomkins led the way with a 10-minute hat-trick which took his tally to 21 tries in nine games. David Hodgson had touched down for the Robins before two tries in five minutes from Tomkins put the favourites in front.
Pat Richards, Josh Charnley and Iain Thornley also touched down for Wigan. Craig Hall reduced the arrears with two tries, but a Liam Farrell score ahead of Tomkins' final try secured an impressive win for the Warriors.
Widnes had to dig deep to beat a spirited Workington 36-0 and progress to the quarter-finals for the first time in eight years.
The seven-time winners were far from their best but in the end had a little too much for the Championship side in miserable conditions at Derwent Park, with Dave Allen touching down twice as the visitors crossed six times and Jack Owens kicking 12 points. Chris Dean, Stefan Marsh, Gareth Hock all went over before the break with Allen's second-half double coming either side of teenager Adam Lawton's score.
The Vikings were without Kevin Brown, who picked up a dead leg in training during the week, but otherwise fielded a pretty much full-strength side. And the part-timers proved tricky opposition for Denis Betts' men and will feel unfortunate not to have at least crossed the line.
Catalan Dragons progressed to the quarter-finals with a devastating thrashing of the York City Knights.
The home side had it all their own way from the seventh minute after trailing to an early Tom Carr penalty.
Eloi Pelissier and Thomas Bosc were the Knight's tormentors as the Dragons raced into a 46-2 half-time lead, second-rower Kevin Larroyer scoring four tries to add to efforts from Daryl Millard, Morgan Escare (two) and Bosc.
Bosc also added seven conversions from eight attempts.