Prop Gethin Jenkins, hooker Matthew Rees and even skipper Sam Warburton could be among those who come under close scrutiny following last weekend's tournament-opening home loss to Ireland. And while Howley is ultimately unlikely to make sweeping changes, players such as Paul James, Richard Hibbard and Justin Tipuric have strong claims up-front.
"When you don't play as well as you can play you come under pressure, because there are good individuals underneath you who want that jersey," Wales assistant coach Mark Jones said in a general observation.
"Pressure is part of this sport, part of your job.
"Player selection is down to form and injury. Ours, for the first game, was predominantly around who we had available.
"In top-level sport there's not much in it. It's about getting the last two or three per cent right on the day and, if you do that, more often than not you will come out on the winning side.
"I know it's a cliche, but all we can focus on is the next game. That has been the strength of this group the last three or four years and, more often than not, we have been successful.
"Do we give the players an opportunity to go out and redeem themselves or do we try and freshen things up and bring some fresh blood in?
"Those are the type of things coaches have got to make decisions on. They are not easy ones, to be honest with you."