Manu Tuilagi's injury provides Luther Burrell with the chance to make a play for the England No13 shirt during the autumn internationals - if given a chance by Stuart Lancaster.
The Leicester Tigers centre has injured a pectoral muscle which will see the British and Irish Lion star almost certainly sidelined for the start of the series against Australia and Argentina before Lancaster and his medical staff reassess the centre's fitness status in mid November.
It comes as a big blow to the Red Rose, quite literally, with Tuilagi proving to be one of the most consistent performers for his national side over the past year, including a flurry of impressive tries during the Six Nations, particularly against France.
With England set to miss their best yard gainer as a result of this setback, Lancaster needs to find someone to fill Tuilagi's large shoes. That man should be Burrell.
The 25-year-old was part of the Red Rose squad which toured Argentina in the summer but didn't win a Test cap as Lancaster stuck with Jonathan Joseph and Kyle Eastmond.
The former is probably the favourite to replace Tuilagi as the perceived next man in line but the England hierarchy should seriously contemplate Burrell as an option.
The Northampton Saints centre, who signed from Sale ahead of the 2012/13 season, has helped his side climb to third this season with wins against Harlequins and Saracens after a string of impressive performances.
In short, Burrell is one of the in-form English centres, and his pace and power can help compensate for the absence of Brad Barritt and Tuilagi.
Burrell told the Northampton Chronicle & Echo: "To be completely honest, I don't really look at it (England) at all.
"This is where it counts for me. It's my club rugby. I want to be playing consistently for this club. If I get anything after that, it's fantastic. But for me it's all about playing well for Northampton Saints at the moment."
Whether Burrell is given the chance by Lancaster is another matter. The Red Rose boss has a history of taking the safe option, particularly in big games, and uncapped Burrell would certainly be a gamble.
But a calculated one!