The lack of a collective bargaining system in La Liga means Real and Barcelona account for about half the TV pot of £481 million.
That helps make them the world's richest clubs by income, with annual earnings close to £500m, and means they can afford to buy the best players and pay the highest wages.
Del Nido has called La Liga "a load of rubbish", saying only the big two have a realistic chance of winning the title, and there is widespread support among other clubs for the introduction of a revenue sharing system like those used in rival European leagues.
However, Real and Barca have shown little sign they are prepared to cede to such demands as they look to protect their status as dominant powers.
Real, who dropped five points in their opening three games this season, have put 15 goals past Sevilla in their last three league meetings including a pair of crushing 6-2 victories in the Andalucian capital.
Under coach Michel, a former Real player, Sevilla are undefeated this term but in recent years have looked a shadow of the side that won consecutive UEFA Cups in 2006 and 2007 and are not even in European competition this season.
Del Nido issued a rallying call to Sevilla fans this week, urging them to get behind the players for the Real clash at the Sanchez Pizjuan while Michel said on Thursday it was a chance for the team to kickstart their campaign.
"I would give my contract if that is what it takes to get a win against Real Madrid and that turned into the start of a positive run," Michel told Sevilla's TV channel.
Barcelona, who visit Sevilla at the end of the month, have won their opening three matches and are two points clear at the top on nine points, five ahead of Real.
New coach Tito Vilanova will be without Andres Iniesta for Barca's trip to Getafe on Saturday after the Spain playmaker returned from international duty with a muscle strain.
Barca have slipped up several times in recent years in their first game after an international break but Cesc Fabregas is confident it will not happen this time.
"You are away from home for 10 days and sometimes there are long journeys and then you have to get back into training again," the Spain midfielder told Barca TV.
"I think we are in good shape and we are returning after a win (1-0 against Georgia in Tbilisi) which is always positive mentally."
Also on Saturday, Malaga host Levante and Valencia are at home to Celta Vigo while on Sunday Athletic Bilbao visit Espanyol and Atletico Madrid entertain Rayo Vallecano.