Wales have won on three of their last four visits to the Scottish capital, and a repeat result on Saturday would keep them in title contention before hosting tournament favourites England later this month.
"I can see it being open," Cuthbert said. "If it's a dry day then I can see it being thrown around a lot, especially with the calibre of player on the pitch. We will be looking to exploit the spaces we see when the game wears down."
He added: "This is our third away game in a row, so it would be good to put a performance in up there to get the win. Then we can concentrate on that last game.
"It's down to desire, that want and hunger to win, and our aggression in defence. We don't want to give teams front-foot ball. That first 20 minutes away from home is key."
Cardiff Blues wing Cuthbert scored his first Six Nations try in last season's appointment with Scotland, and he now boasts an impressive strike-rate of five touchdowns in the last seven championship games.
He also scored the clincher when Wales beat France to be crowned Grand Slam champions last term, and he has already touched down against Ireland and Italy in the current tournament.
Reflecting on events against Scotland 12 months ago, Cuthbert said: "It was my first try for Wales, so I remember it very clearly.
"It's hard to explain how good it is to play for Wales, and to score as well is a special feeling. At the Millennium Stadium it's a feeling you won't get anywhere else, other than hearing the anthem.
"Every try I take in my stride and enjoy every moment. I guess I get in the team because of my scoring record. That is my job - myself, George (North) and Leigh (Halfpenny) - to get those tries and finish off the hard work the forwards do. We work hard on phase-play moves and try to manipulate defences and get myself, George and Leigh with ball in hand as much as possible."