Pikus-Pace bettered Uhlaender on her first two World Cup appearances of the season, finishing sixth to her seventh in Whistler and then third to her 21st in Winterberg.
She then missed the fifth round of the season in La Plagne, which Uhlaender won, while the world title holder was second to Pikus-Pace's third last time out in Altenberg.
However it was Pikus-Pace celebrating victory this time in Koenigssee as she overcame Canadian Sarah Reid with her second run to become the fifth different winner on the circuit this season.
Pikus-Pace also takes the advantage in the Triple Trophy, which incorporates results in Koenigssee, Igls and Sochi, with Marion Thees taking second ahead of Anja Huber in third.
Reid led 2005 World Cup champion Pikus-Pace by just 0.03seconds following the first run after posting 54.14 however a storming second outing from the American saw her win by 0.41.
Pikus-Pace posted 53.34, comfortably bettering her first effort of 54.17, for an overall winning time of 1:47.51minutes as Thees went from fourth to second after also going quicker.
She went 53.63, having gone 54.29 first time out, for second while Huber went from fifth to third as Reid fell away going from first to fifth after a below final run of 54.27.
Canadian Mellisa Hollingsworth jumped from sixth to fourth ahead of Reid while Sophia Griebel, the best German after run one in third, had to make do with sixth.
Britain's Shelley Rudman was then joint-seventh with Michelle Steele of Australia to maintain her position after run one and better teammate Lizzy Yarnold for the first time in three rounds.
Yarnold struggled during the first run and was 16th but improved on her second run to place 11th while world champion Uhlaender was two places ahead in ninth.