The 28-year-old won the second race of the season in Park City however that was her only podium finish from the first four rounds which produced four different victors.
However there was to be no denying the American in La Plagne as she produced a storming first run of 1:03.98minutes for the lead before again posting the fastest time second time out.
Uhlaender went slower in 1:04.24 but that was still significantly quicker than the rest of the field with her overall winning time of 2:08.22 giving her a winning margin of almost half a second.
And, while Uhlaender comprehensively won, Canadian Sarah Reid and German Marion Thees were inseparable as they shared second placed after both finishing on 2:08.71 in La Plagne.
Reid was 0.08s clear of Thees after the first run after posting 1:04.21 but she turned the tide on the second run to draw level with the Canadian as they both were awarded second.
Thees' German teammate Anja Huber was actually third just 0.03 behind Reid after run one but she dropped to fourth after the second, 0.19 further back on the second-placed pair.
Meanwhile Lizzy Yarnold produced a stunning second run to surpass winner last time out in Winterberg Shelley Rudman and finish as the highest Brit in eighth place.
Yarnold posted 1:04.52 second time out, half a second quicker than her first effort, while Rudman was 0.30 slower as she dropped to tenth, both over a second behind Uhlaender.
Meanwhile Donna Creighton's struggles on the World Cup circuit this season continued as she finished 19th in La Plagne in 2:11.53, 3.31 shy of the American winner.