Los Manos' Cristian Sapunaru was given a red card in the 82nd minute, while the Periquitos' Javi Lopez received one in the 79th.
Real Zaragoza controlled the ball for 56.1% of the contest. Los Blanquillos had 14 shots, including four on target.
Helder Postiga had five shots for Real Zaragoza, more than any of his team-mates.
Franco Zuculini went off due to injury in the 91st minute and was replaced by Jose Mari.
Espanyol attempted just three shots, including two on goal.
Los Blanquiazules generated these few opportunities while having possession for 43.9% of the contest.Espanyol's attack was largely blunted throughout the match, and no player registered more than one attempt on goal.
Kiko Casilla pitched in with four stops.Martin Petrov was brought on to replace Cristian Gomez in the 75th minute when the latter went down with an injury.