Eurosport - Spartak's Romulo
The 22-year-old Brazil international, who joined Spartak on a four-year contract from Vasco da Gama in June, tore cruciate ligaments in his knee in a 3-1 win at Rostov.
The defensive midfielder will have surgery in Germany, the Moscow club said on their website.
Spartak, who host Scottish champions Celtic in the Champions League Group G match next week, have several key players out with injuries, including captain Sergei Parshivlyuk and leading striker Welliton.
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