The 26-year-old double Olympic champion is no stranger to the European podium having won six medals since 2006 however only one of them has been gold that coming in 2008 in Kolomna.
In that time Martina Sablikova has won three successive titles but the European crown could well be returning to Dutch hands following Wust's performances in the 500m and 3000m.
Wust placed fourth in the 500m after clocking 39.69 seconds as Sablikova's Czech team-mate Karolina Erbanova posted the quickest time of 38.72 to take the early overall lead.
However Wust was clearly the best in the 3000m with a time of 4:01.25 to head into the 1500m and then the 5000m on Sunday with a points tally of 79.898 and lead of 0.768.
The top four is dominated by the Dutch with Antoinette de Jong, third in the 500m and sixth in the 3,000m, second while Linda de Vries is third and Diane Valkenburg fourth.
Sablikova was the second quickest behind Wust in the 3000m but 16th in the 500m puts her down in seventh overall behind Ida Njatun in fifth and Russia's Yekaterina Lobysheva in sixth.
Meanwhile Olympic champion Sven Kramer moved ever to closer to winning a sixth men's title in seven years with a solid if unspectacular outing in the 1500m.
Kramer, who was seventh in the 500m before storming into the lead following the 5000m, was the eighth quickest in the 1500m after clocking a time of 1:47.49.
That took the Dutchman's points tally to 109.785 for a lead of 0.286 ahead of Havard Bokko, the Norwegian fifth in the 1500m to move up from third to second.
Kramer's compatriot Jan Blokhuijsen swapped places with Bokko after placing tenth in the 1500m while Sverre Lunde Pedersen remained fourth overall with another third.
And Konrad Niedzwiedzki, who posted the quickest time in the 500m for the second time running at the Europeans, jumped up to fifth overall after winning the 1500m in 1:46.32.