Four years ago Britain's Paralympians won 102 medals, including 42 golds in 11 sports, to finish second to hosts China.
They have received £49 million in funding for this cycle and will be expect to continue to winning home team momentum achieved by Team GB at the Olympics.
"British Paralympic sport is better-resourced and in a stronger position than ever before," said UK Sport chair Baroness Sue Campbell.
"We are able to confirm that our goal of holding second place in the Paralympic medal table at our home Games remains on track, in line with our intentions set out back in 2006 when extra funding for Olympic and Paralympic sport was secured."
Team GB chef de mission Andy Hunt was vague on medal targets before the Olympics but British Paralympic Association chief executive Tim Hollingsworth is embracing the challenge set by UK Sport.
"ParalympicsGB is going into these Games better prepared through support from the National Lottery than ever before and we are all ready to give everything to achieve our target of second in the medal table," he said.
"Equally important is the fantastic news that our athletes will be competing in full venues. Winning medals in front of an excited home crowd will give us a great platform to help shift perceptions of Paralympic sport and ensure that our athletes get the recognition they deserve."