Manchester City v Aston Villa
Roberto Mancini is likely to change his whole team from the weekend draw with Arsenal as they prepare to face Villa. Mancini will include youngsters Denis Suarez, Abdul Razak and Luca Scapuzzi in the squad while Carlos Tevez and Mario Balotelli are likely to lead the line after only being used as substitutes against Arsenal. City will be without four players after James Milner and Maicon joined Samir Nasri and Micah Richards on the sidelines. Maicon took a kick to his leg against Madrid and is unlikely to be out for long but Milner is seeing a specialist about a toe problem.
Aston Villa manager Paul Lambert could be forced to make at least one change for his side's tie against Manchester City. Midfielder Stephen Ireland could miss out on a return to his former club after he left the pitch in the 4-1 defeat by Southampton with a suspected broken arm. Chris Herd and Fabian Delph are both available after injuries and could feature but it could still be a game too soon for Marc Albrighton (foot) while Richard Dunne (groin) and Gary Gardner (ligaments) are long-term absentees.
Milton Keynes Dons FC v Sunderland
Jimmy Bullard is expected to be the only absentee for MK Dons. He has been nursing a knee injury and the experienced midfielder may need to see a specialist about the problem. Striker Charlie MacDonald received a cut near an eye against Bury and full-back Jon Otsemobor pulled up at Gigg Lane on Saturday. Both players had to be substituted before half-time but are in contention to face the Black Cats. The Dons also lost Gary MacKenzie before the league game at Bury but the centre-half is another who should be involved in the third-round tie.
Sunderland boss Martin O'Neill was making a series of checks before naming his squad for Tuesday night's trip to MK Dons. Striker Fraizer Campbell suffered a foot injury after coming on as a substitute at West Ham on Saturday, and midfielder Sebastian Larsson left Upton Park with a hamstring problem. O'Neill will also have to decide if central defender Titus Bramble can manage two games in four days, while winger Adam Johnson (thigh) and Carlos Cuellar (hamstring) are unlikely to be risked and Phil Bardsley (ankle) and Wes Brown (knee) are still short of match fitness.
Crawley Town v Swansea City
Claude Davis could return to the Crawley starting line-up. The Jamaican defender had missed the last four matches with a hip injury but was on the bench against Tranmere at the weekend. And boss Richie Barker will be considering throwing Davis back in after watching his side crash 5-2 at home to the League One leaders. Winger Sergio Torres is also available having missed five games with a leg injury, so midfielder Shaun Cooper is the only casualty due to a groin problem. On-loan strikers Jonathan Forte and Nicky Ajose are eligible to play in the competition and could both start up front if Barker opts to rest skipper Gary Alexander.
Michael Laudrup could hand some of Swansea's youngsters a chance to impress against Crawley. The likes of Ashley Williams, Leon Britton, Jonathan de Guzman and Danny Graham were all struggling with various ailments before the weekend defeat to Everton and are likely to be rested. Chico Flores serves the last game of a three-match suspension while Nathan Dyer misses out after his red card against the Toffees. Record signing Pablo Hernandez is a doubt with a knee injury while Itay Shechter will not feature as he observes the Jewish holy day of Yom Kippur.
Bradford City v Burton Albion
Bradford midfielders Ritchie Jones and Ricky Ravenhill are poised to make their first appearances of the season against Burton. Both players have been sidelined since the summer with knee injuries, but could return to the squad and feature as manager Phil Parkinson plans a reshuffle. Winger Garry Thompson and midfielder Zavon Hines are both pushing for recalls, while goalkeeper Matt Duke could return in place of Jon McLaughlin.
Burton boss Gary Rowett will check on the fitness of a handful of players ahead of Albion's trip to League Two rivals Bradford. Without naming names, Rowett revealed that a few of his players are nursing the usual bumps and bruises following the 1-1 league draw against Torquay on Saturday. Among those being monitored will be midfielder Robbie Weir, who played on despite breaking his nose during the first half at Plainmoor.
Preston North End v Middlesbrough
Chris Beardsley continues to be unavailable for Preston as they host Middlesbrough. The former Stevenage striker missed the 3-1 defeat at Walsall on Saturday with a hamstring injury, and is expected to be sidelined for a further seven days. John Welsh, Paul Huntington and skipper John Mousinho all showed no side effects on their return to the side from injury at Banks's Stadium. The Saddlers' clash was Mousinho's first start since the opening day of the season when he tore his hamstring, and he completed 81 minutes without concern. Striker Lee Trundle (knee) and winger Lee Holmes (gashed leg) remain on the sidelines. North End manager Graham Westley made six changes to his starting line-up for the second-round victory against Crystal Palace and is expected to rotate his squad against Tony Mowbray's men.
Middlesbrough defender Jonathan Woodgate is a major doubt. The 32-year-old former England international, who has been plagued by injuries during his career to date, is likely to miss out with a hamstring strain picked up during Friday night's 2-1 Championship victory at Blackburn. Keeper Jason Steele could also miss out with a calf problem suffered during the game at Ewood Park, while defender Adam Reach and striker Ishmael Miller are also doubtful. Reach (ankle) and Miller (groin) did not play at Blackburn and while the former is unlikely to return at Deepdale, the latter is being assessed. Striker Curtis Main (knee) and defender Rhys Williams (ankle) are both out for the foreseeable future after undergoing surgery.
Southampton v Sheffield Wednesday
Southampton are set to ring the changes for tie with Sheffield Wednesday. Nigel Adkins made 11 changes to the starting line-up in the previous round against Stevenage, where they blooded a number of Academy players. Jack Cork could feature as he steps up his return from an ankle injury, while new signing Artur Boruc may be involved in the squad depending on international clearance.
Wednesday will be without Ross Barkley, Rhys McCabe and Martin Taylor with boss Dave Jones planning several changes against his former club. Midfielder Barkley and centre-half Taylor are both cup-tied after already appearing in the competition for Everton and Watford respectively, while McCabe was forced out of Saturday's home defeat to Bolton at half-time with a thigh injury. But Joe Mattock is available following suspension and he could return at right-back, although Daniel Jones is hoping to retain his place. Another defender, Reda Johnson, is still struggling with the foot injury that kept him out against Bolton. Strikers Gary Madine and Chris Maguire are pressing for recalls to the starting line-up and Irish midfielder Paul Corry is in contention for his first appearance for the club.
Chelsea v Wolverhampton Wanderers
John Terry's availability for Chelsea's clash with Wolves remained in doubt this afternoon as he began his Football Association racism hearing. Blues boss Roberto Di Matteo said on Saturday: "We'll see," when asked about the availability of Terry, who denies using a racist slur against Anton Ferdinand. Di Matteo, who remains without Daniel Sturridge (hamstring), may have planned to rest his captain anyway and confirmed he plans to field some fringe and youth players, which could mean debuts for the likes of Marko Marin and Cesar Azpilicueta and a full debut for Victor Moses.
Wolves are set to field a much-changed line-up, with manager Stale Solbakken stating as many as "nine or 10" new faces could be included. Solbakken, who boasts no new injury problems or suspensions, is set to hand starting berths to the likes of David Davis, Danny Batth, Stephen Hunt, Ronald Zubar, Frank Nouble and Georg Margreitter. Solbakken's intentions are not so much a sign of his priorities this season but more his belief in rest and recuperation. Wanderers have played three games in six days as they battle through a gruelling Championship campaign and face a further three in seven - starting at Stamford Bridge.
Swindon Town v Burnley
James Collins and Nathan Thompson are in line to retain their starting places when Swindon entertain Championship outfit Burnley. Striker Collins successfully completed 53 minutes against Bournemouth on Saturday as he returns to fitness following injury, while Thompson starred at right-back in the 4-0 defeat of the Cherries. Left-back Federico Bessone is likely to have to settle for a place on the bench with Di Canio favouring Jay McEveley against Bournemouth.
Junior Stanislas is a major doubt for Burnley. The 22-year-old midfielder was replaced by Cameron Stewart after 45 minutes of the Clarets' 2-1 win at Derby on Saturday with a hamstring problem, and the club will assess the player's fitness before the game at the County Ground. Ben Mee started his first league game of the season in the win against the Rams, and is expected to retain his place in defence. Fellow defender Michael Duff is unlikely to be rushed back for the cup clash having missed the last two games with an Achilles injury. Danny Ings is continuing his recovery from a knee operation, but remains at least six weeks away from a return to the first team.
West Ham United v Wigan Athletic
West Ham boss Sam Allardyce has no fresh injury concerns ahead of his side's clash with Wigan at Upton Park. The Hammers are still without on-loan Liverpool striker Andy Carroll (hamstring) although he has started to train, while the only other absentee is Jack Collison (knee). Yossi Benayoun could be in line to make his first start since returning to the club on loan from Chelsea and Allardyce has hinted striker Modibo Maiga will also be named in his starting XI.
Roberto Martinez has thrown down the gauntlet ahead of Wigan's tie against West Ham with the promise of starting berths next weekend for the players who impress. Martinez has thrown open the competition for places for this weekend's trip to Sunderland, and plans to use the cup match at Upton Park as a litmus test for some of his fringe players.
Leeds United v Everton
Leeds skipper Lee Peltier is a major doubt for his side's clash with Everton. Defender Peltier was forced out of the weekend win over Nottingham Forest with an ankle injury and is not expected to be risked by manager Neil Warnock, who hopes to have him available for Saturday's game at Bristol City. Warnock will also make a late decision on striker Luciano Becchio, who fired his seventh goal in eight appearances this season against Forest despite carrying an ankle injury. Teenager Dominic Poleon scored on his full debut for the club against Forest and will be hoping to resume his partnership up front with Becchio, although Andy Gray provides Warnock with an alternative option. Forward Ross McCormack (ankle), plus midfield pair David Norris (thigh) and Paul Green (knee) remain sidelined, but defender Adam Drury returned at the weekend after a muscle strain and is likely to continue at right-back.
Striker Nikica Jelavic has recovered from a shin injury and returns to the squad for the tie at Elland Road. Defender Tony Hibbert (calf) and Darron Gibson (thigh) are still absent, although the former is expected to have recovered in time for the weekend's visit of Southampton. Manager David Moyes is expected to make a couple of changes but he plans to put out a strong side and defender Sylvain Distin could return having been rested at the weekend.