Stephen Donald returns at fly-half for Bath while Josh Ovens starts at blindside flanker and hooker Lee Mears returns to the front row. Retiring prop Duncan Bell could make his last home appearance after being named on the bench.
Wasps have named a side featuring seven players aged 21 or under for their trip to The Rec. Dom Waldouck starts in midfield while Joe Launchbury switches from the back row to the second-row, with Billy Vunipola at number eight and Sam Jones blindside flanker.
Gloucester, with Carl Hogg in charge following Bryan Redpath's resignation, tackle Sale Sharks for the final Heineken Cup qualification place with Tim Molenaar in midfield and Dave Lewis back at scrum-half in place of Nick Runciman.
Sale have made three changes from the win against Bath, with Will Addison coming into the centres, Cillian Willis replacing Dwayne Peel at scrum-half and Mark Easter starting at blindside flanker.
Nick Evans returns at fly-half for Harlequins' top of the table clash against Leicester in place of Rory Clegg after missing the last two matches through injury.
Geordan Murphy returns to captain Leicester from full-back as the only change to the Tigers line-up that secured an impressive bonus point win at Northampton last week. Graham Kitchener comes in for Craig Newby on the bench and Scott Hamilton covers the backline.
Miles Benjamin, Marcel Garvey, Dale Rasmussen, Chris Fortey and captain Kai Horstmann will all play their final matches for Worcester before moving on to pastures new in the summer.
London Irish start with Steven Shingler at fly-half while props Max Lahiff and Leo Halavatau come into the front row and England Under-20 international plays at blindside flanker.
Exeter start arguably the biggest game in their history with Jason Shoemark at centre and Phil Dollman at full-back, with Luke Arscott moved to the bench. Number eight Richard Baxter will be making his 350th league appearance in Exeter colours.
Northampton have made two changes from the defeat to Leicester which cost them a top four place last week, with Stephen Myler replacing Ryan Lamb at fly-half and Mark Sorenson in for Samu Manoa in the second row.