Lynch, signed for an undisclosed fee from Nottingham Forest in the summer, was shown a straight red card in Wednesday night's win at Sheffield Wednesday and sits out the first of a three-game ban.
Anthony Gerrard is likely to step in alongside Peter Clarke in central defence.
Hammill missed out at Hillsborough due to a knee injury sustained against Derby last weekend and the on-loan Wolves winger is not expected to be included.
Fellow wide man Danny Ward shook off a knock in time to face Wednesday and should continue after turning in a starring role for Simon Grayson's side, while the Terriers boss must decide who to start with up front.
Lee Novak scored in midweek after starting alongside James Vaughan, but summer signing Sean Scannell and Alan Lee provide Grayson with alternative options as Town look to extend their unbeaten run to six league matches.
Blackpool boss Ian Holloway will enjoy the benefit of a fully-fit squad once more.
Holloway shuffled his pack to fine effect when a side displaying six changes romped to a 4-1 victory over Middlesbrough last Tuesday.
On-loan Aston Villa striker Nathan Delfouneso marked his full-debut with a brace and is in line to keep his place alongside recalled captain Barry Ferguson and left-back Stephen Crainey.
"For me as a manager, this is what I've been working towards all of my life," Holloway told the Blackpool Gazette.
"We have a real club here now, instead of just a squad of 16 players.
"This is the best scenario I've ever been in at a club. I'm very excited about the options I have throughout my squad."