The Dutchman, who has enjoyed a successful Classics season over the past few weeks, will instead take part in the Vuelta a Espana while focusing on the upcoming world championships.
"The Tour de France does not really fit in my program," Terpstra, who won the Dwars door Vlaanderen, finished sixth at the Tour of Flanders and fifth in the Paris-Roubaix, told De Telegraaf.
"I will ride the Vuelta a Espana, because that is again ideal preparation for the road world championships. So I have had to choose between the two great races, because both are certainly not possible in a year like this.
"I have started the Tour four years in a row now. In 2010, I got sick and unfortunately had to go home two days after the prologue, and in the other three cases I have had little chance of a stage victory.
"Everyone in the team is also in full agreement with me that the Olympics and world championship races have been better for me to peak.
"This doesn't mean that in future I will never start the Tour again, but my next big goal is the national championships on the road in late June in Kerkrade."