The England international, 20, has suffered extensively with injury problems ever since damaging his ankle in a pre-season fixture against New York Red Bulls in the summer of 2011.
His rehabilitation was prolonged due to a number of setbacks but Wilshere was finally given the chance to pull on the Arsenal red at The Hawthorns after returning to training on September 20.
Wearing the No. 10 shirt for the first time following the sale of Robin van Persie to Manchester City, Wilshere played for 63 minutes before being substituted in a 1-0 defeat.
Fellow midfielder Emmanuel Frimpong also continued his recovery from a knee ligament injury, playing 70 minutes, though he did appear as a substitute in the Carling Cup victory over Coventry City last week.
Wilshere's return to action represents excellent news for an Arsenal side recently deprived of Abou Diaby for up to three weeks.
Wenger cited the fact both players would be available to him this season as a key reason for opting against signing a new midfielder following the sale of Alex Song to Barcelona.