Laura Robson and Heather Watson begin their campaigns with hopes high they can bring some much-needed British success after six of the seven home hopes crashed out on day one.
Watson begins her championship on Court Two where she will face Madison Keys of the US.
Robson takes on 10th seed Maria Kirilenko on Court One following Juan Martin Del Potro against Albert Ramos.
Third up on Court One is Martin Klizan against Tomas Berdych.
Centre Court (1pm)
1-Serena Williams (U.S.) v Mandy Minella (Luxembourg)
1-Novak Djokovic (Serbia) v Florian Mayer (Germany)
4-David Ferrer (Spain) v Martin Alund (Argentina)
Court One (1pm)
Albert Ramos (Spain) v 8-Juan Martin Del Potro (Argentina)
10-Maria Kirilenko (Russia) v Laura Robson (Britain)
Martin Klizan (Slovakia) v 7-Tomas Berdych (Czech Republic)
Court Two (11:30am)
Heather Watson (Britain) v Madison Keys (U.S.)
Dmitry Tursunov (Russia) v 13-Tommy Haas (Germany)
9-Richard Gasquet (France) v Marcel Granollers (Spain)
4-Agnieszka Radwanska (Poland) v Yvonne Meusburger (Austria)