Latest signing Slavomir Peszko, who has agreed a season-long loan from FC Cologne, is expected to fill the position vacated by Michael Kightly in midfield.
Fellow loanee Tongo Doumbia will also hope to feature after joining from Rennes while new-boys Frank Nouble and striker Bjorn Sigurdarson could start.
Defender Danny Batth may also make his long-awaited debut - he was part of the Sheffield Wednesday side which was promoted to the Championship while on loan at Hillsborough last season.
Steven Fletcher, Christophe Berra and Adam Hammill are among those not expected to feature as their futures remain in doub.
Aldershot boss Dean Holdsworth will be without four senior players.
Midfielder Craig Stanley will have to wait for his debut after suffering a broken leg in pre-season.
Goalkeeper Ross Worner is also likely to miss a number of months after being scheduled for a back operation next week.
New defender Guy Branston is unlikely to make his first appearance just yet after suffering an injury in a recent friendly.
Holdsworth's other remaining absentee is striker Danny Hylton as he serves the first of an eight-match ban after being fined for racial abuse.
However, other new signings Oli Lancashire, Craig Reid and Anthony Tonkin and returning Hull loanee Sonny Bradley are expected to start.