Springboks to start uncapped trio against England
Locks Juandre Kruger and Eben Etzebeth were both included in new coach Heyneke Meyer's side for the clash at Durban's Kings Park along with flanker Marcell Coetzee.
A fourth newcomer, prop Coenie Oosthuizen, could make his first appearance off the bench.
The players add a new dimension to an otherwise experienced side following a series of retirements and injuries. The starting 15 still boasts a combined total of 458 Test caps with nine of the players that featured in last year's World Cup quarter-final against Australia retained.
Meyer (pictured) said: "Eben, Juandre, Marcell and Coenie have all put their hands up this season and I know they can succeed at Test level. It is quite a new thing in South African rugby to have two uncapped locks starting. It is a huge step up but I am confident in them. I am very happy for them and their families, and know they will make South Africa proud.
"Although the team is quite young, we still have some experience across the starting 15. The balance in the team is right in the way we want to play against England and we're looking forward to the first Test."
The other main issue in the team was the decision to hand the vice-captaincy to hooker Bismarck du Plessis. Du Plessis is one of the world's best number twos but has still faced a battle for that position and the vice-captain's role from Adriaan Strauss, who will be on the bench. Strauss will take over as vice-captain if and when he replaces Du Plessis.
Meyer announced earlier in the week that the side would be captained by centre Jean de Villiers throughout the three-Test series. Meyer said: "We're fortunate to have a strong leadership core in Jean, Bismarck and - if he gets replaced - Adriaan."
South Africa team to face England in first Test at Kings Park, Durban, on Saturday, June 9
Z Kirchener; JP Pietersen, J de Villiers (capt), F Steyn, B Habana; M Steyn, F Hougaard; T Mtawarira, B du Plessis, J du Plessis; E Etzebeth, J Kruger, M Coetzee, W Alberts, P Spies.
Replacements: A Strauss, C Oosthuizen, F van der Merwe, K Daniel, R Pienaar, P Lambie, W Olivier.