International Football - Germany rest World Cup stars
Only eight members of Loew's 18-man squad were in South Africa, most of them as fringe players.
"After the World Cup and the lengthening of our contracts, it was always going to be the case that we would do without our most established players against Denmark," said Loew, whose contract was extended for another two years after he returned from South Africa.
"We are aware of our responsibility for the form and health for the international players. So, after the great exertion of the World Cup, it is important for them to concentrate on their clubs and preparing well for the new season," Loew added in a statement on the German federation website.
Loew's squad included two uncapped players, defender Sascha Rieter and midfielder Marco Reus.
Germany's next competitive matches will be the Euro 2012 qualifiers away to Belgium and at home to Azerbaijan in September.
Germany play Denmark in Copenhagen on August 11.
Midfielders: Christian Gentner (VfB Stuttgart), Thomas Hitzlsperger (West Ham United), Aaron Hunt (Werder Bremen), Toni Kroos (Bayern Munich), Marko Marin (Werder Bremen), Marco Reus (Borussia Moenchengladbach), Christian Traesch (VfB Stuttgart), Piotr Trochowski (Hamburg SV)