The Blues renew their fierce rivalry with the Spanish giants this week, the fifth season out of the last eight that the sides have squared off in Europe's premier club competition. Most of those clashes have been dogged by controversy, none more so than the most recent at the same stage of the Champions League three years ago.
Drogba's foul-mouthed tirade against referee Tom Henning Ovrebo for failing to award Chelsea several penalties in Barca's away-goals triumph earned the striker a four-match ban - later reduced to three.
But the 33-year-old has also had plenty to celebrate against the Catalans in the past, saying: "It's not only bad memories - we have some good memories as well against Barcelona.
"It's a 50-50, even if they are said to be the best team in the world and have the best player in the world. There are two games. Anything can happen."
Drogba added of 2009: "It was a few years ago, so things have changed since then. But the desire is the same, the desire to beat them. It's going to be a tough game for us but we're ready to play."