Arsene Wenger believes Great Britain's quest for Olympic gold next summer will make life impossible for Premier League managers.
The Arsenal boss also insisted the Olympic football tournament is not a real competition and players should not be allowed to play in both the European Championship and London 2012 next summer.
Wenger said: "If you look at the organisation of the whole summer, it makes life impossible for the clubs and the players especially.At some stage you have to decide how far you can go medically for the players to play so many games under so much pressure.
The Football Association opened the door for the possibility of England players at Euro 2012 potentially turning out for the Great Britain football team, if a schedule could be worked out between England manager Fabio Capello and newly-appointed Olympic head coach Stuart Pearce.
That could potentially affect Arsenal's Jack Wilshere, Kieran Gibbs and Alex Oxlade-Chamberlain, as well as Theo Walcott. Aaron Ramsey is also likely to be involved in Great Britain's 18-man Olympic squad.
Wenger added: "I would say there is already no real break because of the European Championship and the Olympic tournament for me is not a real football tournament, for me the Olympics is for track and field basically."
Wenger insists players require at least four weeks' rest after tournaments and believes playing in both would be unworkable.
He said: "The competition (Olympics)is after the European Championship. The Euros finish on July 1, we start the championship on August 15, we start pre-season training on July 4 or 5, that means we will not have the players after the Euros.
"If we are losing them as well to the Olympic Games I think I will have to sign a licence to practise all over the summer because we will not have players. It cannot work.
"The Olympics finish in mid-August, so imagine a player who has played the Euros and Olympic Games. You think you can use him after that? It's impossible. I don't know what people think when they organise these competitions."