Right-back Richardson missed last weekend's 4-0 win over Derby due to a thigh injury and centre-half Hooiveld was substituted at half-time with a slight hamstring problem.
Brazilian midfielder Guly was also missing against the Rams through illness.
Versatile defender Danny Butterfield, who has not started a league game since October, is fit after a hamstring injury and could return to the squad.
Japan international Tadanari Lee climbed off the bench to score his first goal for Saints against Derby so he may have earned a place in the starting line-up.
Young midfielder Ben Reeves has joined League Two Dagenham on a month's loan.