Barry was forced off less than 30 minutes after he was introduced as a half-time substitute in Saturday's 1-0 win over Norway. The Manchester City midfielder immediately informed Hodgson he would require a scan to discover the extent of the damage, which could put paid to his hopes of appearing at Euro 2012.
With England's official 23-man squad due to be submitted to UEFA by midday on Tuesday, Hodgson said: "We only have a couple of days to sort it out and we can't take any risks. He is a very honest individual and whilst the scan will tell us a lot, if it doesn't give us the answer we want I shall be having a very serious discussion with him."
He added: "He will have to be honest with me and let me know exactly how it is."
If Barry does not make it, Hodgson has strongly hinted that Everton's Phil Jagielka will be the replacement. The move would be understandable as the England boss only named seven defenders in his squad to start with and, including James Milner and Phil Jones, has plenty of central midfield options should his resources become depleted.
Jagielka was outstanding alongside Joleon Lescott in central defence on Saturday, the same defensive pairing that helped secure that excellent win over world champions Spain in November. And it seems the Everton man will get the call, which would make up for the disappointment of missing the World Cup due to injury.
"I am prepared to reconfigure," said Hodgson. "I am not necessarily looking to replace man-for-man in the midfield area because we have a lot of players in that area."
Although the worst is expected of Barry, the medical bulletin is not being feared with quite the trepidation that might have been expected.
Scott Parker came through a 60-minute outing in Oslo with no ill-effects from his recent Achilles injury and, apparently, enough improvement has been shown by Danny Welbeck and Glen Johnson for Hodgson to allay any doubts over their involvement.
"I am not worried about Glen Johnson. I am not worried about Danny Welbeck," said Hodgson. "We have sorted that one out. I am convinced they will be more than fit when they get on the plane to go to Poland."