Laurent Koscielny and Francis Coquelin are both doubts with injuries picked up against AC Milan and Sunderland respectively, while fellow defender Sebastien Squillaci and midfielder Aaron Ramsey are also nursing knocks picked up in that FA Cup defeat.
Mind you, it's not all bad news for Gunners fans, as Carl Jenkinson is back in training following his three-month absence with a stress fracture in his back.
As for Spurs, the news that Tom Huddlestone will be out for the rest of the season may not hit them too hard, as they have had to deal with his absence for most of the campaign. The same could be said for William Gallas, who is also still sidelined.
They are boosted by the news that striker former Arsenal striker Emmanuel Adebayor and midfielder Rafael van der Vaart are both on course to return in time for the short trip to the Emirates as they recover from respective knee and calf problems.
Elsewhere, Aston Villa manager Alex McLeish expects midfielder Fabian Delph to be out for the rest of the season after his loan spell at former club Leeds was curtailed by an ankle injury.
Bolton midfielders Stuart Holden and Lee Chung Yong are both said to be making good progress following their long-term injuries. Trotters boss Owen Coyle is hopeful that Lee could be playing again next month, although insists he will not rush either back for the club's fight against relegation.