It really big impact to MU when they lost Ronaldo, but they still lead by one of the great manager. When MU losing Cantona many years ago people keep saying MU will face big problem and it also happen when Beckham leave the club and Now Ronaldo. The fact is this manager really good on how to overcome this problem.
Hard to predict who is going to win the title since each team have an advantage & disadvantage. Just wait & see for first 5 game then we can start to talk about it.