Matt Prater kicked an NFL record 64-yard field goal to help spark the win.
The victory improved the AFC West-leading Broncos' record to 11-2 with the second-place Kansas City Chiefs at 10-3 with three weeks remaining in the season.
Denver, with two wins against the Chiefs this season, holds the tiebreaker edge over Kansas City.
Manning completed 39-of-59 passes for 397 yards and four touchdowns in Sunday's victory over the 5-8 Titans.
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