Chisora has not fought since suffering a five-round knockout at the hands of British rival David Haye in July 2012 but returns to action at Wembley Arena.
He fights his Argentinian opponent on the undercard of Nathan Cleverly's WBO light-heavyweight title defence against Robin Krasniqi.
With prospective bouts against Robert Helenius and David Price in the offing following Avila, trainer Don Charles says Chisora is ready to once again pursue his dream of world domination.
"No doubt," said Charles. "I believe it very strongly. With just 19 fights on his CV, Dereck’s barely half way through his journey, his quest to the heavyweight championship of the world. I’m very excited about our future.
"Both of those (Helenius and Price) are good names. Personally, I’d prefer Helenius. We’ve already beaten him once but got fleeced so next time we’ll have to make it even more conclusive. I’d prefer not to go to Finland because the ref, as well as the judges, was so biased last time. But Mr Helenius is one of Sauerlands’ top boys and unlikely to travel so if we have to go there again, we will.
"I’m very confident. Styles. No disrespect to Mr Helenius but he’s been very carefully matched and doesn’t show much improvement. He’s very one dimensional, can’t alter his style. A fighter who keeps coming at you like Dereck Chisora is his worst nightmare.
"I understand David Price has secured a rematch with Tony Thompson for the summer which is fantastic news and we wish him well. I expect him to avenge the loss because he was all over Thompson in the first fight until he made the mistake.
"Price-Chisora will have to come later, provided both keep winning. But when it happens, my man wins all day long. They’ve done so much sparring together and I get to observe and analyse. Like Tyson, Dereck has difficulty with opponents his own size but makes a meal of the long, tall guys!"
- Robert Helenius
- Dereck Chisora