The former Sheffield United striker is still struggling with the hamstring strain which forced him to miss last weekend's victory over Derby.
Winger James Henry is also a doubt after he too missed the Rams game with a hamstring problem.
Andy Keogh and Liam Feeney came in for Henderson and Henry, and both scored in the Lions' 2-1 win so they should keep their places.
Skipper Paul Robinson remains sidelined by a pelvic problem which will keep him out for another month.
John Marquis is recovering from a groin op but fellow forward Shaun Batt is fit after a calf injury and scored for the reserves in midweek.
Leeds will be without midfield pair Michael Brown and Rudy Austin, plus suspended defender Jason Pearce .
Jamaica international Austin cracked a bone in his ankle in last week's 6-1 home defeat to Watford and is expected to be sidelined until after Christmas, while Brown sits out an automatic one-game ban after reaching five yellow cards.
Centre-half Pearce was shown a straight red card against Watford for his tackle on Matej Vydra and begins a three-match suspension after Leeds lost their appeal, so Tom Lees, who played the full 90 minutes in England Under-21s' 2-0 win over Northern Ireland in midweek after shaking off an eye injury, is expected to return to the starting line-up.
Patrick Kisnorbo, back in contention in recent weeks following a long-term knee injury, could also figure in manager Neil Warnock's plans.
Winger Ryan Hall is pushing for his first start after making his second appearance off the substitutes' bench last week and striker Luciano Becchio is hoping to return as Leeds chase their first league win in seven matches.
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