In 38 years of trying so far, England have endured 16 failed campaigns in World Cups and Champions Trophies. But Cook has no doubt they can lift the Champions Trophy at Edgbaston.
"The day before a big final ... you can sense that excitement," he said. "The guys are just raring to go ... we're ready to play. I'm fully confident in our guys that we can upset India here tomorrow."
Cook and several of his ODI team-mates have an ever more imminent high-profile assignment in the Ashes, which will dominate the remainder of the summer.
But he sees an overdue victory in a world tournament as a pressing priority in its own right.
"It is very important for us - one of our major goals this summer was to try and win the Champions Trophy," he added.
"Not only will it break that duck of 38 years but also prepare well for the World Cup, if you're looking long-term.
"The lads, in the last two games under pressure, delivered two excellent performances. I can see no reason why we can't do it tomorrow."
Cook has respect but not fear for in-form India, who lost 4-0 in Tests and 3-0 in ODIs on their last bi-lateral trip to this country yet have won every match so far in this tournament.
"They're unbeaten, and have played some very good cricket," he said. "But our record against India last time we played them in England is good. We can certainly take a lot from that."
- Sports & Recreation