The Proteas recorded a 2-0 series win against the same opposition in Dubai last week and the same team will go into the return matches in Johannesburg this Wednesday and in Cape Town on Friday.
Domingo decided against resting AB de Villiers but admitted he will give the one-day international captain a break "at some stage".
The Proteas rested Morne Morkel and JP Duminy ahead of Friday's second T20.
The South Africa coach said he would monitor the 29-year-old De Villiers' workload as a priority over the coming months because of the added pressure he carries as ODI captain, being both a senior batsman and the regular Test wicketkeeper.
Domingo told cricinfo.com: "He is definitely going to have a break at some stage. He has (been) playing cricket non-stop since he was about nine years old.
"He has a lot on his plate so there's every chance he will get one or two T20s off in the not-too-distant future."
Domingo believes batsman Hashim Amla can continue to progress after restarting his T20 career and he admitted he has great confident in his bowlers.
He added: "In T20s, our thought processes with the ball (are) not exactly spot on.
"Although the bowlers did well (last week), we're still bowling balls to certain fields that we shouldn't be bowling.
"Batting-wise, Hashim has just restarted his T20 career and he is a work in progress, although he brings a lot of calmness to the team.
"And then it's just about our pattern of play and nailing that down properly."
Pakistan hope to have the edge on South Africa preparation-wise as they partake in three training sessions before Wednesday's first T20 on Wednesday, while their opponents only regroup in Johannesburg on Tuesday.
Captain Mohammad Hafeez is confident his side are in good form and recalls their 1-0 T20 series victory over South Africa at Centurion in March.
Hafeez registered a career-high 86 in that match, while Umar Gul picked up five for six as Pakistan won by 95 runs after the first match was rained off in Durban two days earlier.
He said: "We put up a good show in the shorter formats and we believe, in this part of the world, we've done reasonably well."
The two countries have come head to head 20 times across all formats of the game this year and Hafeez is hoping the familiarity can help Pakistan put a marked down to measure their own progress.
He added: "When you play too much with each other, sometimes you enjoy and sometimes you are fed up.
"But we are very much ready for this.
"We're both competitive enough teams to make this a good series."
- Sports & Recreation
- South Africa
- AB de Villiers
- Morne Morkel
- Hashim Amla