The Cobblers front man was ruled out of Saturday's 2-0 home win against Aldershot due to a one-match ban, but is set to make an immediate first-team return against the Dons.
Ishmel Demontagnac deputised for Akinfenwa against the Shots but is unlikely to keep his place after being substituted at half-time.
Jake Robinson staked his claim for a starting spot after making an immediate impact from the bench as Demontagnac's replacement, opening the deadlock just three minutes after coming on the field.
Manager Aidy Boothroyd also has Joe Widdowson at his disposal, after the defender made a full recovery from a dead leg.
Luke Guttridge has also returned to training following a foot injury, but is unlikely to feature against Neal Ardley's strugglers.
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