Artell has made a complete recovery from the Achilles injury that has kept him out since the start of October.
The experienced centre-back will provide significant competition for places in a defence that leaked three goals in the opening 25 minutes at Chesterfield last weekend.
However, fellow defender John Johnson, who has also spent several weeks on the sidelines due to a knee injury, will not be considered for selection.
Cobblers boss Aidy Boothroyd will take a more cautious approach with the full-back, who has had two knee operations this season and whose comeback from the first of those was aborted in November.
"Ideally I would like them both to play in a reserve-team game but at the moment I might have to use the games to get them fit if I need them," said Boothroyd.
"Dave Artell will come into contention for Saturday and be on the bench at least. Johnno is still not quite right yet so we'll take our time with him."
Boothroyd could also opt to freshen up his team with the likes of Ishmel Demontagnac, Lewis Hornby, Lewis Wilson and Louis Moult - all of whom were on the bench for the 3-0 defeat at Chesterfield.
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